in the beginner's world, there should be some routes with less demand. My experience is that even at zero of route image (i.e. you did just set up the route, and noone is aware of the route's existence), if you fill less than 1/3 of available demand, then you'll be at 50% of load factor on day one. For example, you put a 50 seater on a 150-demand unserved route, you'll have 25 pax on day one. And most 50 seaters - especially props - are doing small but real profit at 50% load factor. Then route image slowly grows, and you do excellent money, and you can add more flights on the same routes (or a bigger plane - which is less obvious than it seems).
With a caveat : you have to use your planes a lot. Leasing a plane and paying the staff is a fixed cost. To offset this, you have to fly them as much as possible. you can read my full tutorial here :
https://www.airwaysim.com/forum/index.php/topic,71633.0.html - or just try to find ways to fly your aircraft as much as possible during the week. If you fly, let's say turboprops, you should have an aircraft use above 12 hours per day. If you fly single aisle aircraft, you should aim for more, like 14 hours. Exact numbers may vary depending on your airport's location.