If I may offer some personal recommendations.
1. Consider fuel contracts, calculate the cost vs benefits using a projected figure where you will breakeven on the contract price. Don't forget it caters only for departures from base (div2)
2. Your aircraft type are better for shorter sectors, especially with rising fuel prices. Although they consume more fuel per unit, what you will be doing is shifting costs to fixed costs and reducing your exposure to fuel price. However, keep in mind that this is risky since your actual cost per seat kilometre is going to rise, but you can control it. Also try to reduce your turnaround times and increase utilisation to increase your revenue to counter your decreased efficiency.
3. Did I mention utilisation? FLY your planes till they drop! Schedule routes per day so you can monitor each flight performance and then increase or cut routes as appropriate. Don't forget that frequency plays an important role in the game.
4. If you have a route which gives you good profit, increase seat count to reap revenue. Be careful how to interpret LF as sometimes it can be misleading. It's all about profit!
Hope it helps you out.