If you want someone else to build your airlines for you, why not just post your login details and see what happens? (Not a real idea, btw
There is no 'best' place to start, 'best' planes to start with, 'best' places to fly.
If you want good advice, you need to ask more specific questions.
The easiest way to start off profitable is to find a size 5, maybe size 4 airport that has either no airlines based there, or a very small airline. There should be some US airports that fit the bill, I can't see as I'm not in MT5. There are probably some small countries that also fit the bill, try the Bahamas, Trinidad, Azerbaijan, Uzbekistan, all 4 of those and plenty of others have airports that will be easy to start in, IF they are empty. Since you're almost brand new to AWS, you shouldn't pick anywhere that has high competition already.
Once you pick your airport, the best routes to start on are the busiest, shortest, emptiest ones you can find.
Once you pick your airport, the best planes to start with are all from 1 fleet, enough range to fly those short & busy routes, at least 50 seats for props or 100 seats for jets, not fuel guzzlers (25 kg per seat per hour is probably your upper limit when fuel is so expensive, and lower would be better), and that have at least a few of them available in the used market.
If you can afford to lease 6 of the same plane in the first 3 days (ATR, Xian, Fokker might be available), that will work well.