Unless you put yourself other objectives. I had plenty of fun in previous GW3 filling a maximum of destinations airports. I reached 609 of them, iirc, 80 more than my immediate second. It did have an impact on my margin, as you don't fly a Fairchild Metro between Edinburgh & Kangerlussuaq(tech stop in Keflavik), or between Nice & Bobo Dioulasso(with a tech stop in the Algerian desert) unpunished.
I was finally limited by the 600 airplanes out of base limit. I didn't fill Warsaw as I should have, and probably missed around 20 more destinations.
But you'd better have a steady income base before playing with that kind of fun. That's why Wildavidson advice is sound : rentability will allow you to have more fun. I had a huge inter-european network of Ejets & 737 that made the bulk of my benefit, which allowed me to play freely with metros (who were making some money anyways - my level 1 base in Visby with 32 inter-Sweden lines just in metro is one of my best memories, and did have some profitability). Without the extra income that paid for metros purchases, I could not have done this.
He's right : make a lot of money, make your company steady and strong along the decades, and then, only then, play the statistic(s) you want to play on.