A loss at first is somewhat normal until your ci and ri build up from zero. However, looking at a few of your routes tells me that you're disregarding the route planning screen when opening routes. You are flying dc7s on routes that have 7-40 demand. Even when you get ci and ri up, you'll still bleed money using those planes and those routes.
I'd suggest a smaller plane for the lower demand as that will lower your costs and give you a chance