I have. In the previous DOTM game (back under the previous game version, game was 1981-2001 iirc) I ran an airline out of Denver and used them for most of my domestic fleet (had 737s and 757s as well, but I couldn't keep up with the order rate on the 737s). I ultimately replaced them with 737-500s, but that was mainly because the production line closed on me and under the old ordering system I could get lots of a single type in a short period of time.
Fuel/pax wise, iirc, they're similar or slightly better than a 722Adv, though you clean up on frequency and get hammered on longer routes by the slow speed. That was my first airwaysim game, so I don't know if I was actually making money flying them long range, but I flew them as far as the florida panhandle (basically max range) and don't recall the individual aircraft numbers ever going in the red. It was touch and go though when gas got expensive, during several fuel spikes I only held on by my fingernails, and probably only because I owned a lot of the 146s outright and could tap them for collateral.
They're not bad for their time, but in 2007 I'd only keep them long enough to get a CRJ900 or something similar to replace them.